腊红桂教授的"植物分子遗传学和表观基因组学"研究团队, 以模式植物拟南芥和水稻为研究对象, 开展植物表观遗传学和控制水稻重要农艺性状的基因的克隆, 功能研究和应用研究, 包括以下方面:
(1) 拟南芥DNA去甲基化的分子机理和表观基因组学.
(2) 拟南芥基因沉默的分子机理.
(3) 表观遗传学修饰与pre-mRNA转录后剪切加工的关系.
(4) 水稻抗逆基因和控制重要农艺性状(产量, 抗逆性)的基因的定位、克隆, 功能研究和生产应用.
Jiayu Niu, Fei Wang, Chengcheng Yang, Qiwen Ye, Jingxian Huang, Yumei La, Qianqian Wang, Jie Dai2, Tiange Hu, Liran Sang, Peijiang Zhang, Yu Zou, Zhaoyu Zhai, Jian Jin, Dina Abdulmajid, Jingjing Guo, Huhui Chen*, Honggui La*. Identification of Increased Grain Length 1 (IGL1), a novel gene encoded by a major QTL for modulating grain length in rice. Theoretical and Applied Genetics (2024) 137:24 (https://doi.org/10.1007/s00122-023-04531-7).
Xiangyu Wang, Min Wang, Jie Dai, Qianqian Wang and Honggui La. Fine mapping and characterization of RLL6 locus required for anti-silencing of a transgene and DNA demethylation in Arabidopsis thaliana, Frontiers in Genetics, 2022, DOI:10.3389/fgene.2022.1008700 (IF=4.599) [通讯作者].
Zhi Hou, Jie Dai, Changlin Wang, Ying Cheng, Yumei La, Jiayu Niu, Shaoxia Zhou, Honggui La. RLL5, an F-box-containing protein, involved in preventing transgene silencing and in maintaining global DNA methylation in Arabidopsis. Biochemical and Biophysical Research Communications (BBRC), 2022, 609 (2022) 1-8, (IF= 3.575) [通讯作者].
Qianqian Wang, Yumei La, Huihui Xia, Shaoxia Zhou, Zhaoyu Zhai and Honggui La. Roles of MEM1 in safeguarding Arabidopsis genome against DNA damage, inhibiting ATM/SOG1-mediated DNA damage response, and antagonizing global DNA hypermethylation. Journal of Integrative Plant Biology (JIPB), 2022, 64: 87-104 (IF=7.061) [通讯作者]
Wei Miao, Jie Dai, Yutong Wang, Qianqian Wang, Chong Lu, Yumei La, Jiayu Niu, Feng Tan, Shaoxia Zhou, Yufeng Wu, Huhui Chen and Honggui La. Roles of IDM3 and SDJ1/2/3 in Establishment and/or Maintenance of DNA Methylation in Arabidopsis. Plant and Cell Physiology, 2021. 62(9): 1409–1422, (IF=4.799) [通讯作者]
Xiaofeng Zu, Yanke Lu, Qianqian Wang, Yumei La, Xinyue Hong, Feng Tan, Jiayu Niu, Huihui Xia, Yufeng Wu, Shaoxia Zhou, Kun Li, Huhui Chen, Sheng Qiang, Qi Rui, Huaqi Wang and Honggui La. increased Drought Resistance 1 Mutation Increases Drought Tolerance of Upland Rice by Altering Physiological and Morphological Traits and Limiting ROS Levels. Plant and Cell Physiology, 2021, 62(7): 1168 1184, (IF=4.799) [通讯作者]
Yanke Lu, Jie Dai, Liu Yang, Yumei La, Shaoxia Zhou, Sheng Qiang, Qianqian Wang, Feng Tan, Yufeng Wu, Weiwen Kong, Honggui La. Involvement of MEM1 in DNA demethylation in Arabidopsis. Plant Molecular Biology. 2020, 102:307–322 (IF=4.065) [通讯作者]
Wei Miao, Jie Dai, Yumei La, Chong Lu, Jianzhen Zhang, Xinyue Hong, Shaoxia Zhou, Qianqian Wang, Xiangyu Wang, Qi Rui, Feng Tan, Honggui La. Characterization and fine mapping of Arabidopsis RLL3, a locus required for DNA demethylation pathway. Molecular Genetics and Genomics. 2020, 295:81–93 (IF=2.994) [通讯作者]
Weiwen Kong, Xue Xia, Qianqian Wang, Li-Wei Liu, Shengwei Zhang, Li Ding, Aixin Liu, and Honggui La. Impact of DNA Demethylases on the DNA Methylation and Transcription of Arabidopsis NLR Genes. Frontiers in Genetics. 2020. doi: 10.3389/fgene.2020.00460 (IF=4.005) [通讯作者]
Qianqian Wang, Shuai Liu, Chong Lu, Yumei La, Jie Dai, Hongyu Ma, Shaoxia Zhou, Feng Tan, Xiangyu Wang, Yufeng Wu, Weiwen Kong and Honggui La. Roles of CRWN-family proteins in protecting genomic DNA against oxidative damage. Journal of Plant Physiology, 2019, 233: 20~30 (IF=3.615) [通讯作者]
Qianqian Wang, Qianli Guo, Yuanyuan Guo, Jieshu Yang, Min Wang, Xiaoke Duan, Jiayu Niu, Shuai Liu, Jianzhen Zhang, Yanke Lu, Zhi Hou, Wei Miao, Xiangyu Wang, Weiwen Kong, Xiaoming Xu, Yufeng Wu, Qi Rui and Honggui La. Arabidopsis subtilase SASP is involved in the regulation of ABA signaling and drought tolerance by interacting with OST1. Journal of Experimental Botany, 2018, 69: 4403~4417 (IF=7.1) [通讯作者]
Weiwen Kong, Bin Li, Qianqian Wang, Bin Wang, Xiaoke Duan, Li Ding, Yanke Lu, Liwei Liu and Honggui La. Analysis of the DNA methylation patterns and transcriptional regulation of the NB-LRR-encoding gene family in Arabidopsis thaliana. Plant Molecular Biology, 2017, 96: 563~575 (IF=4.065) [通讯作者]
Xiaofeng Zu, Yanke Lu, Qianqian Wang, Peifeng Chu, Wei Miao, Huaqi Wang and Honggui La. A new method for evaluating the drought tolerance of upland rice cultivars. The Crop Journal, 2017, 5(6): 488~498 (IF=3.395) [通讯作者]
Mingguang Lei*, Honggui La* (*contributed equally to this work), Kun Lu, Pengcheng Wang, Daisuke Miki, Zhizhong Ren, Cheng-Guo Duan, Xingang Wang, Kai Tang, Liang Zeng, Lan Yang, Heng Zhangb Wenfeng Nie, Pan Liu, Jianping Zhou, Renyi Liu, Yingli Zhong, Dong Liu, Jian-Kang Zhu. Arabidopsis EDM2 promotes IBM1 distal polyadenylation and regulates genome DNA methylation patterns. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 2014 (IF=10.620) [共同第一作者]
Yu Yang, Honggui La, Kai Tang, Daisuke Miki, Lan Yang, Bangshing Wang, Cheng-Guo Duan, Wenfeng Nie, Xingang Wang, Siwen Wang, Yufeng Pan, Elizabeth J. Tran, Lizhe An, Huiming Zhang* and Jian-Kang Zhu*. SAC3B, a central component of the mRNA export complex TREX-2, is required for prevention of epigenetic gene silencing in Arabidopsis, Nucleic Acids Research, 2017, 45(1): 181-197 (IF=11.797) [第二作者]
Dr. Honggui La was raised in Henan province which is located in the middle part of China. He is now a professor in Department of Biochemistry and Molecular Biology, College of Life Sciences, Nanjing Agricultural University. He became a PhD advisor since 2013. He was elected as a memeber of "Program of Exellent Scientists in Jiangsu province" in 2016.
Dr. La obtained his bachelor degree in Henan Normal University in 1999, and his PhD degree in China Agricultural University in 2004. Later on, he jointed the first-class national biological institute--Institute of Genetics and Developmental Biology, Chinese Academy of Sciences. Afterwards, he went to United States for postdoctral research. His postdoctral research lasted 6 years in 3 universities, Ohio State University (OSU), University of California, Riverside (UCR), and Purdue University. Following the postdoctoral career, he got a job in Shanghai Center for Plant Stress Biology, Chinese Academy of Sciences, as an associate professor. He got his professor position in Nanjing Agricultural University in 2013. He went to Nara Institute of Science and Technology of Japan (NAIST) as a visiting scholar in 2019, which was sponsored by a Joint visiting program between NSFC and JSPS.
Dr. La is currently a member of Editorial Board of an international plant journal--Journal of Plant Physiology.
Dr. La's research group focuses on plant epigenetics and crop molecular biology. For the research of plant epigenetics, model plant Arabidopsis is used to unravel the molecuar mechanisms underlying DNA demethylation, gene silencing, and impact of epigenetic modifications (DNA methylation, histone modifications) on the pre-mRNA splicing. For the research of crop molecular biology, model crop rice is used to discover useful genes responsible for elite agronomic traits, such as rice grain yield, stress tolerance, etc., through map-based cloning strategy. The follow-up studies after gene cloning include functional characterization and practical applications of such elite genes in rice breeding.
Jiayu Niu, Fei Wang, Chengcheng Yang, Qiwen Ye, Jingxian Huang, Yumei La, Qianqian Wang, Jie Dai2, Tiange Hu, Liran Sang, Peijiang Zhang, Yu Zou, Zhaoyu Zhai, Jian Jin, Dina Abdulmajid, Jingjing Guo, Huhui Chen*, Honggui La*. Identification of Increased Grain Length 1 (IGL1), a novel gene encoded by a major QTL for modulating grain length in rice. Theoretical and Applied Genetics (2024) 137:24 (https://doi.org/10.1007/s00122-023-04531-7)
Xiangyu Wang, Min Wang, Jie Dai, Qianqian Wang and Honggui La. Fine mapping and characterization of RLL6 locus required for anti-silencing of a transgene and DNA demethylation in Arabidopsis thaliana, Frontiers in Genetics, 2022, DOI:10.3389/fgene.2022.1008700 (IF=4.599) [通讯作者].
Zhi Hou, Jie Dai, Changlin Wang, Ying Cheng, Yumei La, Jiayu Niu, Shaoxia Zhou, Honggui La. RLL5, an F-box-containing protein, involved in preventing transgene silencing and in maintaining global DNA methylation in Arabidopsis. Biochemical and Biophysical Research Communications (BBRC), 2022, 609 (2022) 1-8, (IF= 3.575) [通讯作者].
Qianqian Wang, Yumei La, Huihui Xia, Shaoxia Zhou, Zhaoyu Zhai and Honggui La. Roles of MEM1 in safeguarding Arabidopsis genome against DNA damage, inhibiting ATM/SOG1-mediated DNA damage response, and antagonizing global DNA hypermethylation. Journal of Integrative Plant Biology (JIPB), 2022, 64: 87-104 (IF=7.061) [通讯作者]
Xiaofeng Zu, Yanke Lu, Qianqian Wang, Yumei La, Xinyue Hong, Feng Tan, Jiayu Niu, Huihui Xia, Yufeng Wu, Shaoxia Zhou, Kun Li, Huhui Chen, Sheng Qiang, Qi Rui, Huaqi Wang and Honggui La. increased Drought Resistance 1 Mutation Increases Drought Tolerance of Upland Rice by Altering Physiological and Morphological Traits and Limiting ROS Levels. Plant and Cell Physiology, 2021, 62(7): 1168 1184, (IF=4.799)
Wei Miao, Jie Dai, Yutong Wang, Qianqian Wang, Chong Lu, Yumei La, Jiayu Niu, Feng Tan, Shaoxia Zhou, Yufeng Wu, Huhui Chen and Honggui La. Roles of IDM3 and SDJ1/2/3 in Establishment and/or Maintenance of DNA Methylation in Arabidopsis. Plant and Cell Physiology, 2021. 62(9): 1409–1422, (IF=4.799)
Yanke Lu, Jie Dai, Liu Yang, Yumei La, Shaoxia Zhou, Sheng Qiang, Qianqian Wang, Feng Tan, Yufeng Wu, Weiwen Kong, Honggui La. Involvement of MEM1 in DNA demethylation in Arabidopsis. Plant Molecular Biology. 2020, 102:307–322 (IF=4.065)
Wei Miao, Jie Dai, Yumei La, Chong Lu, Jianzhen Zhang, Xinyue Hong, Shaoxia Zhou, Qianqian Wang, Xiangyu Wang, Qi Rui, Feng Tan, Honggui La. Characterization and fine mapping of Arabidopsis RLL3, a locus required for DNA demethylation pathway. Molecular Genetics and Genomics. 2020, 295:81–93 (IF=2.994)
Weiwen Kong, Xue Xia, Qianqian Wang, Li-Wei Liu, Shengwei Zhang, Li Ding, Aixin Liu, and Honggui La. Impact of DNA Demethylases on the DNA Methylation and Transcription of Arabidopsis NLR Genes. Frontiers in Genetics. 2020. doi: 10.3389/fgene.2020.00460 (IF=4.005)
Qianqian Wang, Shuai Liu, Chong Lu, Yumei La, Jie Dai, Hongyu Ma, Shaoxia Zhou, Feng Tan, Xiangyu Wang, Yufeng Wu, Weiwen Kong and Honggui La. Roles of CRWN-family proteins in protecting genomic DNA against oxidative damage. Journal of Plant Physiology, 2019, 233: 20~30 (IF=3.615)
Qianqian Wang, Qianli Guo, Yuanyuan Guo, Jieshu Yang, Min Wang, Xiaoke Duan, Jiayu Niu, Shuai Liu, Jianzhen Zhang, Yanke Lu, Zhi Hou, Wei Miao, Xiangyu Wang, Weiwen Kong, Xiaoming Xu, Yufeng Wu, Qi Rui and Honggui La. Arabidopsis subtilase SASP is involved in the regulation of ABA signaling and drought tolerance by interacting with OST1. Journal of Experimental Botany, 2018, 69: 4403~4417 (IF=7.1)
Weiwen Kong, Bin Li, Qianqian Wang, Bin Wang, Xiaoke Duan, Li Ding, Yanke Lu, Liwei Liu and Honggui La. Analysis of the DNA methylation patterns and transcriptional regulation of the NB-LRR-encoding gene family in Arabidopsis thaliana. Plant Molecular Biology, 2017, 96: 563~575 (IF=4.065)
Xiaofeng Zu, Yanke Lu, Qianqian Wang, Peifeng Chu, Wei Miao, Huaqi Wang and Honggui La. A new method for evaluating the drought tolerance of upland rice cultivars. The Crop Journal, 2017, 5(6): 488~498 (IF=3.395)
Mingguang Lei*, Honggui La* (*contributed equally to this work), Kun Lu, Pengcheng Wang, Daisuke Miki, Zhizhong Ren, Cheng-Guo Duan, Xingang Wang, Kai Tang, Liang Zeng, Lan Yang, Heng Zhangb Wenfeng Nie, Pan Liu, Jianping Zhou, Renyi Liu, Yingli Zhong, Dong Liu, Jian-Kang Zhu. Arabidopsis EDM2 promotes IBM1 distal polyadenylation and regulates genome DNA methylation patterns. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 2014 (IF=10.620)
Yu Yang, Honggui La, Kai Tang, Daisuke Miki, Lan Yang, Bangshing Wang, Cheng-Guo Duan, Wenfeng Nie, Xingang Wang, Siwen Wang, Yufeng Pan, Elizabeth J. Tran, Lizhe An, Huiming Zhang* and Jian-Kang Zhu*. SAC3B, a central component of the mRNA export complex TREX-2, is required for prevention of epigenetic gene silencing in Arabidopsis, Nucleic Acids Research, 2017, 45(1): 181-197
